Topical Calcineurin Inhibitors

Learn about topical calcineurin inhibitors—offering relief for inflammatory skin conditions, especially when steroid treatments are less suitable for long-term use.

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Topical calcineurin inhibitors (TCIs) are a class of medications used to treat certain inflammatory skin conditions.

Unlike steroids, TCIs work by modulating the immune response in the skin cells, reducing inflammation and managing conditions like eczema and atopic dermatitis.

Why Use It?

TCIs are prescribed to manage inflammatory skin conditions where steroid treatments may not be suitable for long-term use due to concerns about side effects.

These inhibitors, including tacrolimus and pimecrolimus, target the immune response in the skin, effectively reducing inflammation, itching, and flare-ups associated with conditions like eczema.

They are particularly beneficial for sensitive areas of the skin, such as the face and skin folds.

Who Uses It?

Individuals with moderate to severe eczema or atopic dermatitis, especially those who haven’t responded well to other treatments, may benefit from using TCIs.

These medications are commonly prescribed for children and adults who require long-term management of chronic inflammatory skin conditions.


Topical calcineurin inhibitors offer an alternative treatment approach for managing inflammatory skin conditions like eczema.

Their ability to target the immune response in the skin provides relief and helps in controlling flare-ups, particularly in sensitive areas where traditional steroid treatments might pose risks.

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